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KMID : 0358420110540030127
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Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 3 p.127 ~ p.131
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PROPHYLACTIC ANTIEMETICS THERAPY AGAINST GYNECOLOGIC CANCER CHEMOTHERAPY
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Lee Keun-Ho
Kwon Yong-Il
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Abstract
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Nausea and vomiting associated with gynecologic cancer chemotherapy are experienced by most of patients receiving chemotherapy. Assessment of vomiting risk by chemotherapy and risk factor are mandatory for rescue of chemotherapy induced nausea and vomiting (CINV). Piled-up evidence based medicine result in prophylactic antiemetics guideline from American Society of Clinical Oncology, Multinational Association for Supportive Care in Cancer, and National Comprehensive Cancer Network. Combination of serotonin receptor antagonist, dexamethason, and with/without NK1 antagonist is the best prophylaxis in patients receiving highly and moderate emetogenic chemotherapy. Other new regimens (palonosetron, transdermal granisetron) are introduced to relieve the active symptom of delayed CINV. Comprehensive understading of pathophysiology of CINV and tailored therapy for the patients are vital in prophylactic antiemetics therapy against gynecologic cancer chemotherapy.
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KEYWORD
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Nausea, Vomiting, Antiemetics, Guideline
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